PHYSIS LABORATORY happiness inside – 60 capsules

• Anti-oxidant action
• Contributes to the normal functioning of the metabolism
• Contributes to the normal functioning of the liver
• Contributes to the normal functioning of the immune system

Red algae of the genus Gracilaria are rich in bioactive compounds (vitamins, polyphenols, proteins etc.), that can promote one’s health. The polysaccharides (PLS) of Gracilaria spp. have been well characterized for their functional activities such as anti-oxidant, anti-inflammatory, anti-viral, hypolipidaemic, immunomodulatory and other physiological activities. Moreover, these PLS are considered to be effective agents promoting intestinal health, having anti-diarrheal effect and improving metabolic syndrome1,2,3. Zinc is an important trace element for the normal functioning of the human metabolism. Its deficiency could bring diverse symptoms affecting the immune and gastrointestinal system, as well as the skin4,5. Wheatgrass (Triticum aestivum) is a rich source of vitamins A, C, E and B1, minerals, trace elements and anti-oxidant enzymes. Therefore, it can be considered as a detoxification agent that exerts anti-oxidant action6,7. Dandelion (Taraxacum officinale) is a herb and its extract provides bioactive compounds, that contribute to the normal functioning of liver and spleen. Moreover, Dandelion extract has anti-oxidant, anti-inflammatory, analgetic, diuretic and other properties8,9,10. Black pepper (Piper nigrum) contains an alkaloid, called piperine, which is widely known for its pharmaceutical properties, such as its anti-oxidant, analgesic, anti-inflammatory, anti-hypertensive, anti-microbial, immuno-modulatory, hepatoprotective and other actions. Black pepper is not only widely used as a spice, but it also contributes to the normal functioning of the immune system consisting of potential nutraceutical and pharmaceutical agents11,12. Turmeric (Curcuma longa) is a widely known herb. Its extract is rich in curcumin, a polyphenol, which the last decades is considered to have therapeutic effects based on pre-clinical studies. Curcumin has an important role in prevention and treatment of various diseases. Its efficacy against diabetes, osteoarthritis, inflammatory bowel disease, autoimmune, neurological, lung, liver and cardiovascular diseases are well proven, due to its anti-oxidant, anti-inflammatory, anti-microbial, anti-mutagenic, immunomodulatory and other properties13,14,15,16.

1. Sun, X., Duan, M., Liu, Y., Luo, T., Ma, N., Song, S. & Ali, C. (2018). The beneficial effects of Gracilaria lemaneiformis polysaccharides on obesity and the gut microbiota in high fat diet-fed mice. Journal of Functional Foods, 46: 48-56. https://doi.org/10.1016/j.jff.2018.04.041
2. Bezerra, F.F., Lima, G.C., Sousa, N.A., Sousa, W.M., Costa, L.E.C., Costa, D.S.D., Barros, F.C.N., Medeiros, J.V.R., & Freitas, A.L.P. (2018). Antidiarrheal activity of a novel sulfated polysaccharide from the red seaweed Gracilaria cervicornis. Journal of Ethnopharmacology, 224: 27-35. https://doi.org/10.1016/j.jep.2018.05.033
3. Chan, P.T., Matanjun, P., Yasir, S.M., & Tan, T.S. (2014). Antioxidant and hypolipidaemic properties of red seaweed, Gracilaria changii. Journal of Applied Phycology, 26: 987–997. https://doi.org/10.1007/s10811-013-0135-z
4. Glutsch, V., Hamm, H., & Goebeler, M. (2019). Zinc and skin: an update. Journal of the German Society of Dermatology, 17 (6): 589-596. https://doi.org/10.1111/ddg.13811
5. Kim, B., & Lee, W.W. (2021). Regulatory Role of Zinc in Immune Cell Signaling. Molecules and Cells, 44(5): 335-341. https://dx.doi.org/10.14348%2Fmolcells.2021.0061
6. Das, P., Mandal, S., Gangopadhyay, S., Das, K., Mitra, A.G., Dasgupta, S., Mukhopadhyay, S., & Mukhopadhyay, A. (2015). Antioxidative and anticarcinogenic activities of methylpheophorbide a, isolated from wheat grass (Triticum aestivum Linn.). Natural Product Research, 30(4): 474-7. https://doi.org/10.1080/14786419.2015.1022775
7. Shakya, G., Balasubramanian, S., Hoda, M., & Rajagopalan, R. (2017). Inhibition of metastasis and angiogenesis in Hep-2 cells by wheatgrass extract – an in vitro and in silico approach. Toxicology Mechanisms and Methods, 28(3): 205-218. https://doi.org/10.1080/15376516.2017.1388460
8. Martinez, M., Poirrier, P., Chamy, R., Prüfer, D., Schulze-Gronover, C., Jorquera, L., & Ruiz, G. (2015). Taraxacum officinale and related species-An ethnopharmacological review and its potential as a commercial medicinal plant. Journal of Ethnopharmacology, 169: 244-62. https://doi.org/10.1016/j.jep.2015.03.067
9. Chen, W., Fan, H., Liang, R., Zhang, R., Zhang, J., & Zhu, J. (2019). Taraxacum officinale extract ameliorates dextran sodium sulphate‐induced colitis by regulating fatty acid degradation and microbial dysbiosis. Journal of Cellular and Molecular Medicine, 23: 8161-8172. https://doi.org/10.1111/jcmm.14686
10. Pfingstgraf, I.O., Taulescu, M., Pop, R.M., Orăsan, R., Vlase, L., Uifalean, A., Todea, D., Alexescu, T., Toma, C., Pârvu, A.E. (2021). Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure. Antioxidants, 10(4): 504. https://dx.doi.org/10.3390%2Fantiox10040504
11. Salehi, B., Zakaria, Z.A., Gyawali, R., Ibrahim, S.A., Rajkovic, J., Shinwari, Z.K., Khan, T., Sharifi-Rad, J., Ozleyen, A., Turkdonmez, E., Valussi, M., Tumer, T.B., Monzote Fidalgo, L., Martorell, M., & Setzer, W.N. (2019). Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications. Molecules, 24(7): 1364. https://doi.org/10.3390/molecules24071364
12. Takooree, H., Aumeeruddy, M.Z., Rengasamy, K.R.R., Venugopala, K.N., Jeewon, R., Zengin, G., & Mahomoodally, M.F. (2019). A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications. Critical Reviews in Food Science and Nutrition, 59: 210-243. https://doi.org/10.1080/10408398.2019.1565489
13. Srivastava, S., Saksena, A.K, Khattri, S., Kumar, S., & Dagur, R.S. (2016). Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial. Inflammopharmacology, 24(6): 377-388. https://doi.org/10.1007/s10787-016-0289-9
14. Gupta, S.C., Prasad, S., & Aggarwal, B.B. (2016). Anti-inflammatory Nutraceuticals and Chronic Diseases. Springer International Publishing, Switzerland.
15. Kocaadam, B., & Şanlier, N. (2017). Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical Reviews in Food Science and Nutrition, 57(13): 2889-2895. https://doi.org/10.1080/10408398.2015.1077195
16. Memarzia, A., Khazdair, M.R., Behrouz, S., Gholamnezhad, Z., Jafarnezhad, M., Saadat, S., & Boskabady, M.H. (2021). Experimental and clinical reports on anti-inflammatory, antioxidant, and immunomodulatory effects of Curcuma longa and curcumin, an updated and comprehensive review. Biofactors, 47(3): 311-350. https://doi.org/10.1002/biof.1716