Be Agile by Physis Laboratory is a dietary supplement which contains MSM and plant extracts of Boswellia serrata, Harpagophytum procumbens, Tanacetum parthenium and Equisetum arvense. Boswellia’s extract contributes to the good physical function of joints, while Tanacetum’sand Equisetum’s extracts contribute to the regular blood microcirculation.
Methylsulfonylmethane (MSM) is a natural organosulfur compound found in fruits, vegetables and grains and it is consumed worldwide as a non-toxic dietary supplement. Due to its anti-inflammatory action, it is used as a therapeutic agent for the effective treatment of inflammatory conditions, such as arthritis, alleviating from arthritic symptoms and improving the physical function of patients. MSM has also an anti-oxidant action and therefore it protects the human body reducing the oxidative stress that can be caused following endurance exercise. It is also suggested for the relief of seasonal allergic rhinitis symptoms. Boswellia serrata is a well-known plant with a long history in herbal medicine due to its therapeutic properties. Boswellia’s extract is used for the reduction of osteo-arthritis pain and the improvement of body’s physical and functional ability. Harpagophytum procumbens (Devil’s Claw) is one of the most studied herbaceous plants, because it can affect key mechanisms that may lead to inflammatory conditions. Its extract appeared effective as analgetic in the reduction of arthritic symptoms, such as pain and stiffness. Tanacetum parthenium, which is commonly known as Feverfew, is also an herb been used for medical purposes and specifically for the treatment of inflammatory disorders. Nowadays, there are clinical data indicating that the compounds of Feverfew extract exert anti-migraine properties, while contributing to the smooth microcirculation. Last but not least, the plant extract of Equisetum arvense, a perennial herb well-known as horsetail, has anti-oxidant and anti-inflammatory properties contributing to the regular microcirculation. Meanwhile, due to its bioactive phytochemicals, it is considered as an effective candidate for the treatment of osteoporosis and bone regeneration.
Butawan, M., Benjamin, R.L., & Bloomer, R.J. (2017). Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients, 9 (3): 290. https://doi.org/10.3390/nu9030290
Hewlings, S., & Kalman, D.S. (2018). Evaluating the Impacts of Methylsulfonylmethane on Allergic Rhinitis After a Standard Allergen Challenge: Randomized Double-Blind Exploratory Study. JMIR Research Protocols, 7 (11): e11139. https://doi.org/10.2196/11139
Dragos, D., Gilca, M., Gaman, L., Vlad, A., Iosif, L., Stoian, L., & Lupescu, O. (2017). Phytomedicine in Joint Disorders. Nutrients, 9 (1): 70. https://doi.org/10.3390/nu9010070
Majeed, M., Majeed, S., Narayanan, N.K., & Nagabhushanam, K. (2019). A pilot, randomized, double‐blind, placebo‐controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytotherapie Research, 33: 1457-1468. https://doi.org/10.1002/ptr.6338
Menghini, L., Recinella, L., Leone, S., Chiavaroli, A., Cicala, C., Brunetti, L., Vladimir‐Knežević, S., Orlando, G., & Ferrante, C. (2019). Devil’s claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data. Phytotherapie Research, 33 (9): 2152-2162. https://doi.org/10.1002/ptr.6395
Mncwangi, Ν., Chen, W., Vermaak, I., Viljoen, A.M., & Gericke, N. (2012). Devil’s Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens. Journal of Ethnopharmacology, 143: 755–771. https://doi.org/10.1016/j.jep.2012.08.013
Badole, S., & Kotwal, S. (2014). Equisetum arvense: Ethanopharmacological and Phytochemical review with reference to osteoporosis. International Journal of Pharmaceutical Science and Health Care, 1 (4): 2249-5738.
Bessa-Pereira, C., Gomes, P.S., Costa-Rodrigues, J., Almeida-Palmas, R., Vieira, L., Ferranz, M.P., Lopes, A., & Fernandes, M.H. (2012). Equisetum arvense hydromethanolic extracts in bone tissue regeneration: in vitro osteoblastic modulation and antibacterial activity. Cell Proliferation, 45 (4): 386-396. https://doi.org/10.1111/j.1365-2184.2012.00826.x
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