Acerola (Malpighia emarginata) is an important source of several bio-active compounds and other nutrients such as phenolics, vitamins, metals etc. It is also widely known as a rich source of ascorbic acid or vitamin C. Vitamin C has anti-oxidant capacity contributing to the maintenance of the redox integrity of human cells, but also to the optimal functioning of the immune system. Zinc is an important trace element for the cellular growth and differentiation contributing to the reinforcement of body’s antioxidant defense and the normal functioning of the immune system. Moreover, zinc and vitamin C are considered to benefit people reducing the symptoms and/or duration of respiratory tract infections like the common cold. Propolis is the bee-glue, that is produced from bees during the construction of their hives. This natural compound is widely known for its anti-oxidant and anti-inflammatory action and its potential cardio- and neuroprotective activity. Another bee product is the royal jelly, that was found to have anti-oxidant, immunomodulatory, anti-diabetic, hypocholesterolemic etc. effects. Colostrum is the first milk that is produced after mammals’ parturition. Colostrum contains a range of anti-microbial peptides and proteins with intense anti-bacterial action, immune-regulatory factors and bioactive oligosaccharides. According to evidence, colostrum has the ability to maintain or improve immune system’s defense, but also to maintain the integrity of gastro-intestinal mucosa, giving protection against detrimental conditions like inflammation. Αndrographis paniculata is a medical herb and its extract is traditionally used due to its anti-inflammatory and anti-microbial action, stimulating the immune system, preventing from the respiratory tract infection and reducing joint pains. Elderberry, Sambucus nigra, is widely known for its anti-bacterial and anti-viral action having health-promoting properties. Due to its bioactive compounds, elderberry extract contributes to the relief of symptoms’ severity and reduction of the duration of viral infection. Astragalus membranaceus is a popular traditional immunomodulating herb, which is believed to exert anti-oxidant, anti-aging and anti-viral effect, as well as it contributes in regulation of blood’s glucose and lipids. Moreover, there is evidence that suggest that it is a potential effective cardioprotective factor against viral myocarditis. Thyme (Τhymus vulgaris) and oregano extract (Origanum vulgare) are rich in carvacrol, a component with anti-oxidant and anti-inflammatory action. Carvacrol seems to improve lung functioning having positive effects against respiratory symptoms of humans with lung disorders.