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First of all, what is glutamine? It is the most abundant free amino acid within the human muscle and blood. It can be found circulating in the blood, as well as stored in the skeletal muscles and liver, in concentrations ranging from 10- to 100-fold higher than any other amino acid. (1)
Glutamine is a building block for protein and involved in many vital functions. It is required for rapidly dividing cells, including those of the gut, and is a precursor of the brain neurotransmitter glutamate.
Certain factors such as heavy exercising can lower the glutamine levels in the body. Glutamine supplements cause a rapid rise in cellular glutamine levels and glutamine stores in muscle.
Glutamine is utilized in a number of vital functions, including protein synthesis and production of the nucleotide units that make up DNA and RNA.
It is an important energy source for cells lining the gut and immune cells and critical for healthy gut and immune function. (1,2) It is also a precursor of the brain neurotransmitter glutamate. (3,4)
Because of its importance in many cellular functions, glutamine is consumed at especially high rates during activities involving intense exercise. (1) People who engage in heavy exercise can affect their glutamine levels, causing stress to their body and immune systems. (5,6)
Supplementing with glutamine can be important to a serious athlete, someone challenged with muscle loss or someone who wants to help maintain optimal immune function and energy level under heavy stress. (6,7)
Glutamine can also act as a fuel for some tissues as well as for components of the immune system such as lymphocytes and macrophages.
The function of glutamine in stimulating glycogen synthase, the enzyme that controls the synthesis and storage of glycogen fuel in muscles and liver, may provide a mechanism by which glutamine supplements promote enhanced fuel stores. (5)
Studies indicate supplementing with glutamine can effectively raise glutamine concentrations in circulation and in muscle tissue, promote a healthy inflammatory response and support antioxidant defenses to maintain muscle health. (8,9)
Take one (1) capsule once or twice per day on an empty stomach, or as directed by a healthcare practitioner.
1 Int J Mol Sci. 2017;18(5)
2 Yonsei Med J. 2011;52(6):892-7.
3 Nutrients. 2018;10(11)
4 J Neural Transm (Vienna). 2014;121(8):799-817.
5 Nutrients. 2019;11(4)
6 J Nutr. 2008;138(10):2045s-2049s.
7 J Occup Environ Med. 2019;61(2):e33-e42.
8 Nutrition. 2014;30(5):602-11.
9 Life Sci. 2014;94(2):130-6.
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